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  • Title: [The stimulating effect of destabilase, a component of Hirudo medicinalis salivary gland secretion, on sensory neuron neurite growth in organotypic culture].
    Author: Chalisova NI, Zhuravskiĭ SG, Penniiaĭnen VA, Berezhnoĭ SN, Artamonova II, Zavalova LL, Baskova IP.
    Journal: Tsitologiia; 1999; 41(1):48-52. PubMed ID: 10380285.
    Abstract:
    The effect of destabilase, a component of Hirudo medicinalis salivary gland secret, was investigated in organotypic tissue culture of dorsal root ganglia (DRG) of 10-11-day old chick embryos. Native destabilase in concentrations 0.01 and 0.05 ng/ml was active, inducing a more intensive neurite growth in DRG that in the control. The stabilizing activity of destabilase was lost following reverse-phase chromatography. Neurite-stimulating effects of the drug "pyjavit" is due presumably to neurite-stimulating activity of destabilase.
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