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  • Title: [Castleman's disease in the retroperitoneal region].
    Author: Pérez García FJ, Martínez Gómez FJ, Fernández Gómez JM, Regadera Sejas FJ, Rodríguez Martínez JJ, Sanchez Trilla A, San Martín Blanco A, Seco Navedo MA.
    Journal: Arch Esp Urol; 1999 May; 52(4):388-92. PubMed ID: 10380331.
    Abstract:
    OBJECTIVE: To describe a case of Castleman's disease presenting as a retroperitoneal mass, with special reference to the differential diagnosis from other retroperitoneal lesions. The histological features, variants, clinical manifestations, etiopathogenesis and treatment of Castleman's disease are reviewed. METHODS: A 64-year-old male presented with voiding symptoms and hypogastric pain. An ultrasound scan showed a 5 x 6 cm mass located behind the bladder and above the prostate, which was confirmed by an abdomino-pelvic CT scan. RESULTS: Retroperitoneal sarcoma was suspected and the mass was resected. The histopathological analysis showed giant lymphoid hyperplasia (vascular hyaline variant of Castleman's disease). CONCLUSIONS: Retroperitoneal Castleman's disease is a lymphoproliferative disorder with two well-defined histological types and a mixed variant. Although this lesion is frequently localized to the mediastinum (71%), extrathoracic lesions have been described. Definitive diagnosis is based on the postoperative pathological findings.
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