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  • Title: Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A.
    Author: Mizuta T, Fujiwara M, Hatta T, Abe T, Miyano-Kurosaki N, Shigeta S, Yokota T, Takaku H.
    Journal: Nat Biotechnol; 1999 Jun; 17(6):583-7. PubMed ID: 10385324.
    Abstract:
    We have investigated the ability of antisense phosphorothioate oligonucleotides to enhance the survival of mice infected with influenza A virus. The oligonucleotides were complementary to sequences surrounding the translation initiation codons of the viral PB2 or PA genes (PB2-as or PA-as, respectively) of the influenza A virus RNA polymerases. Intravenous administration of PB2-as in a complex with a cationic liposome, Tfx-10, significantly prolonged the mean survival time in days and increased overall survival rates of mice infected with the influenza A virus. Liposomally encapsulated PB2-as inhibited viral growth in lung tissues and reduced pulmonary consolidations. Liposomally encapsulated PB2-as could be an effective therapeutic agent against influenza A virus.
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