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  • Title: Splenic and hepatic hemozoin in mice after malaria parasite clearance.
    Author: Levesque MA, Sullivan AD, Meshnick SR.
    Journal: J Parasitol; 1999 Jun; 85(3):570-3. PubMed ID: 10386458.
    Abstract:
    Hemozoin (malaria pigment) is found in many tissues during malaria infections. In mice that have self-cured from Plasmodium yoelii and Plasmodium chabaudi infections, liver hemozoin concentration and total content decreased for 6-9 mo after parasite clearance. However, both spleen hemozoin concentration and total hemozoin content increased dramatically during this time period. Thus, hemozoin or hemozoin-laden macrophages continue to accumulate in murine spleens for at least several months after malaria parasitemia becomes undetectable.
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