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  • Title: Design of scytalone dehydratase inhibitors as rice blast fungicides: derivatives of norephedrine.
    Author: Basarab GS, Jordan DB, Gehret TC, Schwartz RS, Wawrzak Z.
    Journal: Bioorg Med Chem Lett; 1999 Jun 07; 9(11):1613-8. PubMed ID: 10386946.
    Abstract:
    Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
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