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  • Title: Effect of 5-hydroxytryptamine infusion on microcirculation in the rabbit masseter muscle measured by laser-Doppler flowmetry.
    Author: Kurita H, Ernberg M, Tominaga K, Alstergren P, Kopp S.
    Journal: Arch Oral Biol; 1999 May; 44(5):377-82. PubMed ID: 10391494.
    Abstract:
    The aim was to test the hypothesis that 5-hydroxytryptamine (5-HT) influences the microcirculation of the masseter muscle. Rabbit masseters were infused with increasing concentrations of 5-HT (10(-9)-10(-5) M) on the experimental side and with saline on the control side. The effect on microcirculatory blood flow was measured by laser-Doppler flowmetry. The intramuscular temperature was recorded to monitor the influence of tissue temperature. 5-HT infusion resulted in a statistically significant decrease in blood flow at the lowest concentration (10(-9) M) (median; -11.2%: Wilcoxon signed-rank test; p<0.05). At concentrations greater than 10(-9) M, there was no significant change in blood flow. This study shows a decrease of microcirculatory blood flow in the rabbit masseter following 5-HT infusion (10(-9) M).
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