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  • Title: [Characteristics of reactogenic and immunogenic properties of the children's variant of the domestic vaccine, "Gep-A-in-Vak", against hepatitis A].
    Author: Ikoev VN, Gorbunov MA, Maĭdaniuk AG, Karpovich LG, Kalashnikova TV, Bektimirov TA, Karpova EV, Nemtsov IuV, Muntlieva MA, Kriuk NI.
    Journal: Vopr Virusol; 1999; 44(3):133-6. PubMed ID: 10392439.
    Abstract:
    Russian cultural concentrated inactivated vaccine protecting from hepatitis A--Hep-A-in-vac was used for immunization of children. The vaccine is slightly reactogenic and completely safe in children aged 3-17 years vaccinated twice in a dose of 0.25 ml. Double immunization of seronegative children with a 1-month interval led to conversion in 89.7% children. In 64.1% children titers of antibodies to hepatitis A virus reached 20 mIU/ml and higher, which indicates rather high antigenic activity of the vaccine.
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