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  • Title: NGD 94-1 as an agonist at human recombinant dopamine D4.4 receptors expressed in HEK293 cells.
    Author: Gazi L, Sommer B, Nozulak J, Schoeffter P.
    Journal: Eur J Pharmacol; 1999 May 21; 372(3):R9-10. PubMed ID: 10395031.
    Abstract:
    The atypical antipsychotic, clozapine has some selectivity for dopamine D4 receptors and is a silent antagonist at these receptors. NGD 94-1 (2-phenyl-4(5)-[4-(2-pyrimidinyl)-piperazin-1-yl-methyl]-imidazole ) is a highly selective dopamine D4 receptor ligand recently introduced as a putative antipsychotic mimicking the dopamine D4 receptor antagonist effects of clozapine. We show that NGD 94-1 is not silent. It behaved as an agonist in human embryonic kidney 293 cells expressing human recombinant dopamine D4.4 receptors. This questions the clinical use of NGD 94-1.
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