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  • Title: [An ileal ulcer and diaphragm-type colonic stenosis due to diclofenac].
    Author: Aguirre Palacio A, Romero Gómez M, Grilo Reina A, Rafel Ribas E.
    Journal: Gastroenterol Hepatol; 1999 May; 22(5):232-4. PubMed ID: 10396105.
    Abstract:
    Nonsteroidal anti-inflammatory drugs (NSAID) are used extensively in the general population. It's well known the adverse effects of NSAID over the upper gastrointestinal tract and small intestine. Enteric-coated and slow release preparations were created in order to prevent those effects. We describe a woman case who took diclofenac for many years and developed both ileal ulceration and diaphragm-like colonic structure. Lesions in lower gastrointestinal tract were infrequent but severe; the lesion were seen on colonoscopy but not on barium studies; the physiopathology of these lesions remains uncertain; and the most efficacy attitude is the suppression of diclofenac.
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