These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Metabolism of 3,3',4,4',5-penta- and 2,2',3,3',4,4'-hexachlorobiphenyls in rats].
    Author: Haraguchi K, Hirose Y, Masuda Y, Kato Y, Kimura R.
    Journal: Fukuoka Igaku Zasshi; 1999 May; 90(5):210-9. PubMed ID: 10396877.
    Abstract:
    Following the i.p. administration of 3,3',4,4',5-pentachlorobiphenyl (CB126) and 2,2',3,3',4,4'-hexachlorobiphenyl (CB128) to rats, blood, liver, lung, kidney, adipose tissue and feces were analyzed for the metabolites. CB126 was biotransformed to three hydroxylated metabolites identified as 4-OH-3,3',4',5'-tetraCB, 4-OH-3,3',4',5,5'-pentaCB and 5-OH-3,3',4,4',5'-pentaCB at about 1:7:2 ratio, whereas to two methylthio metabolites as 5-MeS- and 6-MeS-3,3',4,4',5'-pentaCBs at 1:2 ratio. Among the metabolites, only 4-OH-3,3',4',5,5'-pentaCB was detected in all tissues and blood. The ratio of metabolite/unchanged CB126 was 1:1.3 in blood and 1:162 in liver, indicating the high blood affinity of this metabolite. Trace amounts of 5-methylsulfonyl-3,3',4,4',5'-pentaCB was also detected in the liver. CB128 was biotransformed to 5-OH-, 5-MeS- and 6-MeS-2,2',3,3',4,4' hexaCBs which were excreted to feces in about 5:5:1 ratio. No metabolites were detected in blood and any tissues except for liver where trace amounts of 5-hydroxylated metabolite was present, indicating the low tissue affinity of hydroxylated metabolites from CB128.
    [Abstract] [Full Text] [Related] [New Search]