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  • Title: Phlebosclerosis of the colon with positive anti-centromere antibody.
    Author: Kitamura T, Kubo M, Nakanishi T, Fushimi H, Yoshikawa K, Taenaka N, Furukawa T, Tsujimura T, Kameyama M.
    Journal: Intern Med; 1999 May; 38(5):416-21. PubMed ID: 10397079.
    Abstract:
    A 56-year-old woman with symptoms of chronic bowel disease presented a peculiar calcification of the mesenteric vein of the ascending to transverse colon on barium enema study. The resected colon was hard and black. Histo-pathologic examinations demonstrated fibrous change of the colon with a calcified and hyaline-deposited mesenteric vein. No cell infiltration was observed. These findings were compatible with phlebosclerosis and also with systemic sclerosis. Positive anti-centromere antibody and Raynaud's phenomenon, hallmarks of a variant systemic sclerosis, the CREST syndrome were observed. We therefore speculated that the pathogenesis of the phlebosclerosis of the colon is related to the CREST syndrome.
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