These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [In vitro sensitivity of Plasmodium falciparum isolates from Gabon to chloroquine and cycloguanil].
    Author: Pradines B, Mabika Mamfoumbi M, Keundjian A, Lebeau C, Fusai T, Owono Medang M, Rogier C, Parzy D, Kombila M.
    Journal: Bull Soc Pathol Exot; 1999 May; 92(2):91-4. PubMed ID: 10399596.
    Abstract:
    The in vitro susceptibility of 91 Plasmodium falciparum isolates obtained from malaria-infected children living near Libreville (Gabon) was evaluated against chloroquine and cycloguanil (biologically active metabolite of proguanil), using an isotopic micro-drug susceptibility test. In vitro resistance to chloroquine and cycloguanil was observed in 83% (35/42) and in 38% (30/78) of the patients, respectively. Our data showed that 41% (16/39) of Gabonese field isolates were resistant both to chloroquine and cycloguanil. These findings are of great importance because they might indicate imminent chloroquine-proguanil failure, and there are not many affordable antimalarial drugs to replace chloroquine-proguanil combination.
    [Abstract] [Full Text] [Related] [New Search]