These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Spectroscopic studies of PhTX facilitated cation movement across membranes.
    Author: Huang X, Borhan B, Matile S, Nakanishi K.
    Journal: Bioorg Med Chem; 1999 May; 7(5):811-4. PubMed ID: 10400333.
    Abstract:
    Philanthotoxins, noncompetitive inhibitors of the nicotinic acetylcholine receptor and various glutamate receptors, were found to be capable of mediating cation transport across lipid bilayers. With respect to the relatively weak binding constants of these amphiphilic polyamines to neuronal receptor proteins, this finding implies that their interaction with cell membranes might have to be considered in addition to that with protein receptors to fully understand the molecular mechanism of these neurotoxins.
    [Abstract] [Full Text] [Related] [New Search]