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  • Title: Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway.
    Author: Hashimoto A, Kurosaki M, Gotoh N, Shibuya M, Kurosaki T.
    Journal: J Biol Chem; 1999 Jul 16; 274(29):20139-43. PubMed ID: 10400627.
    Abstract:
    Two adaptor molecules, Grb2 and Shc, have been implicated in the extracellular signal-regulated kinase (ERK) activation by receptor tyrosine kinases such as the epidermal growth factor receptor (EGFR). Here we show that the EGF-mediated ERK activation is abolished by loss of Grb2, whereas this response is not affected by loss of Shc. Conversely, the EGF-mediated c-Jun N-terminal kinase (JNK) activation is dependent on Shc, but not Grb2. These findings strongly support distinct roles for Grb2 and Shc in controlling ERK and JNK activation after EGF stimulation.
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