These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).
    Author: Uneyama C, Uneyama H, Torii K, Akaike N.
    Journal: Int J Mol Med; 1999 Aug; 4(2):163-9. PubMed ID: 10402483.
    Abstract:
    Megakaryocytes respond to externally applied agonists showing a periodic K+ current that reflects oscillation in cytoplasmic calcium concentration ([Ca2+]i). We have revealed several signal transducing factors that are involved in the K+ current oscillation of megakaryocytes. In this megakaryocyte system, it is relatively easy to determine what point of the signal transduction pathway a drug affects. In addition, as a progenitor cell, megakaryocytes resemble platelets which have important roles in many diseases. Therefore, this experimental system can be used for evaluation of new drugs.
    [Abstract] [Full Text] [Related] [New Search]