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  • Title: Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction.
    Author: Favre H, Benhamou A, Finidori J, Kelly PA, Edery M.
    Journal: FEBS Lett; 1999 Jun 18; 453(1-2):63-6. PubMed ID: 10403376.
    Abstract:
    A family of suppressors of cytokine signaling (SOCS) has recently been identified of which two members have been shown to block growth hormone (GH) signaling. Dose-response experiments were conducted in 293 cells and SOCS-1 and SOCS-3 were shown to inhibit the transcriptional activation of a GH-responsive element and suppressed Jak2 tyrosine kinase activity. SOCS-2 had two opposite effects: at low concentrations it inhibited GH-induced STAT5-dependent gene transcription, but restoration of GH signaling was observed at higher concentrations. In cotransfection studies, SOCS-2 was able to block the inhibitory effect of SOCS-1 but not that of SOCS-3 on GH signaling. These findings suggest that a major function for SOCS-2 is to restore the sensitivity to GH by overcoming the initial inhibitory effects of other endogenous SOCS molecules.
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