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  • Title: Mechanism of antiviral activity of triterpenoid saponins.
    Author: Simões CM, Amoros M, Girre L.
    Journal: Phytother Res; 1999 Jun; 13(4):323-8. PubMed ID: 10404540.
    Abstract:
    Triterpenoid saponins are naturally occurring sugar conjugates of triterpenes possessing various biological activities, including antiviral action. Two substances isolated from natural sources were tested against herpes simplex virus type 1 replication. They did not show evidence of cytotoxicity under antiviral test conditions. The triterpenoid saponin, isolated from a Brazilian plant (s21), represents the oleanane group and inhibited herpes simplex virus type 1 DNA synthesis. The triterpenoid saponin, isolated from a Chinese plant (s17), represents the ursane group and seemed to inhibit viral capsid protein synthesis of herpes simplex virus type 1.
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