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  • Title: Typing of clinical herpes simplex virus type 1 and type 2 isolates with monoclonal antibodies.
    Author: Liljeqvist JA, Svennerholm B, Bergström T.
    Journal: J Clin Microbiol; 1999 Aug; 37(8):2717-8. PubMed ID: 10405430.
    Abstract:
    The purpose of this study was to evaluate the performance of a herpes simplex virus (HSV) type 1-specific anti-glycoprotein C-1 monoclonal antibody (MAb) and a type 2-specific anti-glycoprotein G-2 MAb for typing of 2,400 clinical HSV-1 isolates and 2,400 clinical HSV-2 isolates, respectively, using an enzyme immunoassay. The anti-HSV-1 MAb showed sensitivity and specificity of 100%, and the anti-HSV-2 MAb showed a sensitivity of 99.46% and 100% specificity, indicating that these MAbs are suitable for typing of clinical HSV isolates.
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