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  • Title: [Presentation of obsessive-compulsive symptoms in a patient with schizophrenia treated with clozapine].
    Author: Stengler-Wenzke K.
    Journal: Psychiatr Prax; 1999 May; 26(3):145-6. PubMed ID: 10412713.
    Abstract:
    PURPOSE: Clozapine is an atypical antipsychotic agent for the treatment of schizophrenic patients whose symptoms do not respond to traditional antipsychotic drugs. The emergence of obsessive-compulsive symptoms during treatment of clozapine has been reported in some case studies. We report on the case of a 31-year old man with chronic schizophrenia who had shown obsessive-compulsive symptoms during treatment with clozapine. RESULTS: A 31-year old patient with treatment refractory schizophrenia was treated with clozapine. During clozapine treatment, positive symptomatology decreased, but after 4 months after starting clozapine the patient showed obsessive and compulsive symptoms. This symptomatology had previously not been a feature of this patient's illness. CONCLUSIONS: Obsessive-compulsive symptoms were observed during treatment of clozapine in a schizophrenic patient. This may be explained either by the serotonin-receptor antagonism of clozapine or its atypical dopaminergic receptor effects.
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