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  • Title: ESBRA-Nordmann 1998 Award Lecture: Visual P3 as a potential vulnerability marker of alcoholism: evidence from the Amsterdam study of children of alcoholics. European Society for Biomedical Research on Alcoholism.
    Author: Van Der Stelt O.
    Journal: Alcohol Alcohol; 1999; 34(3):267-82. PubMed ID: 10414601.
    Abstract:
    Recent data from the Amsterdam Study of Children of Alcoholics add to the evidence for considering the P300 or P3 component of the event-related potential (ERP) as a potential vulnerability marker of alcoholism. In this study, multi-channel ERPs were recorded from 7- to 18-year-old children of alcoholics (COAs) and age- and sex-matched low-risk controls using several experimental paradigms, including a visual novelty oddball task and a visual selective attention task. The results indicated that differences between COAs and controls in the visual P3 amplitude: (1) can be elicited both actively by task-relevant target stimuli and passively by irrelevant novel stimuli; (2) are a function of both the attentional relevance and the target properties of the eliciting stimulus; (3) are mediated by multiple brain generators, rather than by a single generator; (4) originate from a difference in the strength, rather than in the spatial configuration, of the underlying brain generators; (5) cannot be accounted for by differences in visual attention-related earlier occurring ERP components; and (6) can be moderated by current behavioural and emotional problems, general intellectual ability, and socio-economic background. These findings support the notion that a relatively small visual P3 amplitude in COAs reflects heritable biases in attention and information processing that are related to their increased vulnerability to alcoholism.
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