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  • Title: Renal excretion of monovalent cations during functional adrenalectomy in conscious sheep.
    Author: Foster JL, Harrison FA.
    Journal: Q J Exp Physiol Cogn Med Sci; 1975 Jul; 60(3):193-206. PubMed ID: 1041515.
    Abstract:
    In sheep with both adrenals removed and one re-implanted in the neck, functional adrenalectomy was produced in conscious undisturbed animals by occluding the blood supply to the transplanted gland. Functional adrenalectomy caused a fall in potassium excretion and a very large increase in sodium excretion and was reversed by aldosterone. Hydrocortisone infusions slightly increased potassium excretion and reduced solute-free water reabsorption. Preliminary evidence suggests that potassium secretion into urine was still occurring during the 8 hr period of adrenal occlusion and functional adrenalectomy.
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