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  • Title: Activated astrocytes display increased 5-HT2a receptor expression in pathological states.
    Author: Wu C, Singh SK, Dias P, Kumar S, Mann DM.
    Journal: Exp Neurol; 1999 Aug; 158(2):529-33. PubMed ID: 10415157.
    Abstract:
    In human brain tissues from patients dying with cerebral infarction, hypertensive encephalopathy, Alzheimer's disease, Huntington's disease, frontotemporal dementia, and Creutzfeldt-Jakob disease there is an activation of astrocytes. Such activated astrocytes display GFAP and strong 5-HT(2A), but not 5-HT(2B) or 5-HT(2C), receptor immunoreactivity; this 5-HT(2A) reaction has not been observed in normal, nonactivated astrocytes. It is suggested that an up-regulation of 5-HT(2A) receptors may be part of an early response reaction in astrocytes, possibly designed to maintain homeostasis or to induce secondary message pathways involving trophic factors or glycogenolysis.
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