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  • Title: [Basic examination of hepatitis C virus (HCV) core protein quantitative method and the clinical significance in during the follow-up of the patients after interferon treatment].
    Author: Suyama Y, Mishima S, Iwata Y, Ishikura H, Shibata H, Masuda J.
    Journal: Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi; 1999; 10(1):13-9. PubMed ID: 10415445.
    Abstract:
    We evaluated the basic efficacy and clinical usefulness of "Imucheck F-HCV Ag-core(KOKUSAI)" (Ag-Core). This kit has been developed using monoclonal antibodies against hepatitis C virus (HCV) core protein. This character is different from RT-PCR assay or branched DNA assay, which have been developed for the detection of HCV-RNA. The reproducibility of Ag-Core assay was supported by vigorous mixture of reagents during the manual pretreatment of samples. The correlation between Ag-Core assay and Amplicor HCV (RT-PCR) assay was relatively good (correlation coefficient: r was 0.735 and the qualitative accordance rate was 96.6%). The change of viral load during the IFN-alpha treatment was also in good accordance between the values determined by Ag-Core and Amplicor-HCV assay. Since it is simple, cheaper and faster than the Amplicor-HCV assay. Quantitation of HCV core protein by the Ag-Core assay is useful for monitoring the therapeutic efficacy of IFN-alpha treatment.
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