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  • Title: [Familial fatal insomnia: a human prion disease which opens the door to a greater understanding of the thalamus].
    Author: Barriga F, Ruiz-Domínguez JA, Velayos JL.
    Journal: Rev Med Univ Navarra; 1997; 41(4):224-8. PubMed ID: 10420962.
    Abstract:
    In 1986, Lugaresi [1] described fatal familial insomnia (FFI), an inherited prion disease, characterised by untreatable insomnia and dysautonomia. The most severe neuropathological changes have been found in the mediodorsal (MD) and anterior (A) thalamic nuclei. The data lead to think that the thalamus could play an important role in the wake-sleep cycle and other vegetative and endocrine circadian activities, specially MD and A.
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