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  • Title: [Isolation, crystallization, and preliminary x-ray study of a Fab fragment of monoclonal antibody against human interleukin-2 and its complex with antigenic peptide].
    Author: Mikhaĭlova IIu, Mareeva TIu, Tsygannik IN, Mikhaleva II, Onoprienko LV, Vikhrov AA, Markvicheva EA, Panghorn W, Duax W, Nesmiianov VA, Pletnev VZ.
    Journal: Bioorg Khim; 1999 Apr; 25(4):247-52. PubMed ID: 10422589.
    Abstract:
    Antigen-binding fragments (Fab) of mouse monoclonal antibodies to human interleukin-2 were obtained in preparative quantities by a modified procedure. These Fab-fragments were shown to be homogeneous according to the isoelectric focusing method. Various monocrystals of these free Fab-fragments and their complexes with the antigenic peptide corresponding to the 59-72 sequence of interleukin-2 were obtained. These were shown to be suitable for X-ray and were preliminarily studied by X-ray.
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