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  • Title: Tolerance induction by transdermal glyceryl trinitrate in rats.
    Author: De la Lande IS, Stafford I, Horowitz JD.
    Journal: Eur J Pharmacol; 1999 Jun 11; 374(1):71-5. PubMed ID: 10422642.
    Abstract:
    Mechanisms of mild glyceryl trinitrate tolerance in rats (transdermal application; 15 mg/day/2 days) were examined in isolated aortic rings contracted with phenylephrine. Tolerance to glyceryl trinitrate was comparable in both endothelium-intact and -denuded vessels; the maximum relaxation decreased to 70-80% and the EC50 increased 3-4-fold. There was minimal cross-tolerance to acetylcholine (1.7-fold increase in EC50) and none to sodium nitroprusside. The results suggest that mild tolerance to glyceryl trinitrate in rats is mediated by mechanisms which are predominantly endothelium-independent and which produce little activation of the cellular mechanism responsible for cross-tolerance.
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