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  • Title: Adrenomedullin-like immunoreactivity in the rat hypothalamo-neurohypophysial tract.
    Author: Ueta Y, Hara Y, Setiadji VS, Isse T, Shibuya I, Kitamura K, Kangawa K, Matsuo H, Eto T, Hattori Y, Yamashita H.
    Journal: Peptides; 1999; 20(2):199-204. PubMed ID: 10422875.
    Abstract:
    Adrenomedullin-like immunoreactivity in the hypothalamo-neurohypophysial tract in colchicine-treated and hypophysectomized rats was examined by immunohistochemistry. Adrenomedullin-like immunoreactive (AM-LI) neurons were localized in the hypothalamic areas, including the paraventricular nuclei and the supraoptic nuclei. Abundant AM-LI fibers and varicosities were found in the hypothalamoneurohypophysial tract and the internal zone of the median eminence in the colchicine-treated and hypophysectomized rats, whereas in control rats few AM-LI fibers were observed. These results suggest that the axons of the AM-LI neurons in the hypothalamus may terminate in the neurohypophysis.
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