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  • Title: [The future of antifungal agents. Non azole antifungal agents].
    Author: Maesaki S, Hossain MA, Sasaki E, Hashiguchi K, Higashiyama Y, Yoshitsugu Y, Tomono K, Tashiro T, Kohno S.
    Journal: Nihon Ishinkin Gakkai Zasshi; 1999; 40(3):157-61. PubMed ID: 10423510.
    Abstract:
    We investigated the efficacy of non-azole antifungal agents. Long circulating immunoliposomal amphotericin B was potent in murine invasive pulmonary aspergillosis. The concentration of AMPH-B was still high in the lung after 6 hours of 34A-PEG-liposomal AMPH-B. Lipid nanosphere amphotericin B (NS-718) showed efficacy against pulmonary aspergillosis in rats and pulmonary cryptococcosis in mice. The renal toxicity of NS-718 was estimated to be lower than that of AMPH-B from the results of the toxicity study in the rat infusion model. FK 463, a novel (1,3)-beta-D-glucan synthase inhibitor, showed efficacy against azole-resistant Candida albicans in murine experimental disseminated candidiasis. FK463 could be a promising drug and the therapy of choice for azole resistant C. albicans infection.
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