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  • Title: PATIC: a conformationally constrained photoisomerizable amino acid.
    Author: Zhang J, James DA, Woolley GA.
    Journal: J Pept Res; 1999 May; 53(5):560-8. PubMed ID: 10424352.
    Abstract:
    The synthesis of a conformationally constrained photoisomerizable amino acid, phenylazo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (PATIC), is described. This amino acid can be incorporated into peptides using standard Fmoc procedures and can be accommodated within alpha-helical structures albeit with some loss of stability of the structure. PATIC can serve as a useful building block for the synthesis of photoregulated peptides and proteins.
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