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  • Title: Preparation and characterization of protein-loaded poly(epsilon-caprolactone) microparticles for oral vaccine delivery.
    Author: Benoit MA, Baras B, Gillard J.
    Journal: Int J Pharm; 1999 Jul 05; 184(1):73-84. PubMed ID: 10425353.
    Abstract:
    This paper describes the conditions of preparation of poly(epsilon-caprolactone) (PCL) microparticles with a mean size between 5 and 10 microm, obtained by a double emulsion-solvent evaporation technique, suitable for oral vaccine delivery. Bovine serum albumin (BSA) was used as water-soluble model antigen for encapsulation. Different parameters influencing the microparticle size, the BSA loading and entrapment efficiency were investigated. Spherical, smooth and homogeneously distributed microparticles were produced with a BSA loading and entrapment efficiency reaching, respectively, 5% (w/w) and 30%. Polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) analyses of BSA released from these particles confirmed that the entrapped protein seemed to remain unaltered by the protein encapsulation process.
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