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  • Title: Longitudinal, transverse, and diffuse nail hyperpigmentation induced by hydroxyurea.
    Author: Hernández-Martín A, Ros-Forteza S, de Unamuno P.
    Journal: J Am Acad Dermatol; 1999 Aug; 41(2 Pt 2):333-4. PubMed ID: 10426924.
    Abstract:
    Hydroxyurea is a cytostatic agent used in patients with myeloproliferative disorders that may produce nail hyperpigmentation, most frequently longitudinal melanonychia. We present a patient treated with hydroxyurea whose nails showed several patterns of nail hyperpigmentation, including longitudinal and transverse bands, and a diffuse darkening of the nail matrix.
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