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  • Title: Effect of dietary supplementation of vitamin E in partial inhibition of Russell's viper venom phospholipase A2 induced hepatocellular and microsomal membrane damage in rats.
    Author: Mukherjee AK, Maity CR.
    Journal: Acta Physiol Hung; ; 85(4):367-74. PubMed ID: 10431608.
    Abstract:
    The current investigation furnishes a good correlation between the alpha-tocopherol content of the liver and microsomes and corresponding inhibition of Russell's viper venom phospholipase A2 inflicted damage to them. Dietary supplementation of d1-alpha-tocopherol at a concentration of 100 mg and 200 mg per kg of diet displayed less damage caused by venom phospholipase A2 in sharp contrast to the vitamin E deficient rats. alpha-tocopherol due presumably to the formation of complexes with the phospholipid hydrolysis products of the membranes, plays a significant role in membrane stabilization.
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