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Title: The enantioselectivity of the cellular deoxynucleoside kinases. Author: Wang J, Chattopadhyaya J, Eriksson S. Journal: Nucleosides Nucleotides; 1999; 18(4-5):807-10. PubMed ID: 10432682. Abstract: Cytosolic thymidine kinase (TK1) and deoxycytidine kinase (dCK) and the mitochondrial thymidine kinase (TK2) and deoxyguanosine kinase (dGK) phosphorylate deoxynucleosides and their analogs. Recombinant human TK1 only phosphorylated beta-D Thd, but recombinant TK2, dCK and dGK all phosphorylated equally well beta-D and beta-L as well as to some extent alpha-D and alpha-L deoxynucleosides.[Abstract] [Full Text] [Related] [New Search]