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  • Title: Synthesis and biological evaluation of polyaminated 2',3'-dideoxy-3'-thiacytidine prodrugs.
    Author: Camplo M, Mourier N, Chermann JC, Kraus JL.
    Journal: Nucleosides Nucleotides; 1999; 18(4-5):879-80. PubMed ID: 10432700.
    Abstract:
    The syntheses and biological evaluation of polyaminated 2',3'-dideoxy-3'-thiacytidine have been performed. A new lead was found to increase the in vitro antiviral potency (syncitia formation on MT-4 cell line) of two order magnitude greater than the parent nucleoside drug. Moreover, the in vitro activity on HIV macrophages was found to be more than 3 log greater than the activity of the parent drug 1.
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