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  • Title: Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3'-azido-2',3'-dideoxythymidine.
    Author: Egron D, Périgaud C, Gosselin G, Aubertin AM, Imbach JL.
    Journal: Nucleosides Nucleotides; 1999; 18(4-5):981-2. PubMed ID: 10432724.
    Abstract:
    The synthesis and in vitro anti-HIV activity of tBuSATE phosphoramidate derivatives of AZT incorporating several methyl-esterified alpha-amino acids are reported. The biological evaluation strongly supports the hypothesis that such compounds exert their anti-HIV effects via intracellular delivery of the corresponding 5'-mononucleotide.
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