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  • Title: Long term effect of splenectomy on patients operated on for cancer of the left colon: a retrospective study.
    Author: Konstadoulakis MM, Kymionis GD, Leandros E, Ricaniadis N, Manouras A, Krespis E, Alexiou D, Androulakis G.
    Journal: Eur J Surg; 1999 Jun; 165(6):583-7. PubMed ID: 10433144.
    Abstract:
    OBJECTIVE: To find out if accidental splenectomy during colonic resection influences the survival of patients with colon cancer. DESIGN: Retrospective clinical study. SETTING: University hospital, Greece. SUBJECTS: Twenty-five patients with colonic cancer (13 Dukes' B and 12 Dukes' C) who had accidental splenectomy during resection of the left colon (n = 22) or the sigmoid (n = 3) between 1973 and 1990. Each study patient was matched with control patients for age, sex, Dukes' stage, grade, site of tumour, date, type of operation and number of blood transfusions. MAIN OUTCOME MEASURES: The five year actuarial and disease free survival estimated by the Kaplan-Meier product limit method. RESULTS: There were significantly more infective postoperative complications (6/25 compared with 0/25, p = 0.02) in patients who had a splenectomy. The incidence of metastases (p = 0.07) and the five-year disease free (p = 0.08) and overall survival (p = 0.1) were lower but not significantly so in patients who had a splenectomy compared with controls. CONCLUSIONS: Splenectomy significantly increases the number of infective postoperative complications in patients with colonic cancer. Although there was a trend for shorter disease-free survival after splenectomy, it seems that splenectomy had no impact on survival.
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