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  • Title: The effect of nefazodone on clozapine plasma concentrations.
    Author: Taylor D, Bodani M, Hubbeling A, Murray R.
    Journal: Int Clin Psychopharmacol; 1999 May; 14(3):185-7. PubMed ID: 10435773.
    Abstract:
    The cytochrome enzyme p4503A4 (CYP3A4) is thought to play a major part in the human metabolism of clozapine. Nefazodone is a potent and specific in-vivo inhibitor of CYP3A4. We co-administered nefazodone and clozapine in six patients and found that mean clozapine levels rose by 4% of baseline and norclozapine levels by 16%. Based on these observations, it is inferred that inhibition of CYP3A4 in vivo has minimal effects on clozapine metabolism. Nefazodone appears to be safe when co-administered with clozapine.
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