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  • Title: tRNAs and proteins are imported into mitochondria of Trypanosoma brucei by two distinct mechanisms.
    Author: Nabholz CE, Horn EK, Schneider A.
    Journal: Mol Biol Cell; 1999 Aug; 10(8):2547-57. PubMed ID: 10436011.
    Abstract:
    Import of tRNA into the mitochondrial matrix of Trypanosoma brucei was reconstituted in vitro. Efficient import required the hydrolysis of externally added ATP and was shown to be a carrier-mediated process depending on proteinaceous receptors on the surface of mitochondria. A partly synthetic tRNA(Tyr) as well as a physiological tRNA(Lys) were imported along the same pathway. Contrary to import of all matrix-localized proteins, tRNA import does not require a membrane potential. Furthermore, addition of an excess of import-competent tRNA had no effect on import of a mitochondrial matrix protein. In summary, these results show that tRNAs and proteins in T. brucei are imported by fundamentally different mechanisms.
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