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  • Title: [Congenital malformations in twins].
    Author: Nazer J, Cifuentes L, Bazzano M.
    Journal: Rev Med Chil; 1999 Feb; 127(2):158-64. PubMed ID: 10436695.
    Abstract:
    BACKGROUND: A higher prevalence of congenital malformations among twins than among single has been reported in the literature. AIM: To study the incidence of congenital malformations in twins in the maternity hospital of the University of Chile in the period 1983-1997. MATERIAL AND METHODS: As part of the Latin American Collaborative Study of Congenital Malformations, every newborn in the maternity hospital was examined by a neonatologist and congenital malformations were recorded in a special file. RESULTS: In the study period there were 48.663 deliveries of single pregnancies and 448 deliveries of twin pregnancies, giving birth to 886 twins borns alive and 17 stillbirths (1.9% mortality). Of these, there were 423 twins, 17 triplets, a sextuple delivery and two siamese. Seven point one percent of twins born alive and 6.5% of single newborns had a congenital malformation. The prevalence of malformations in twins and single stillbirths was 35.2 and 17.2% respectively (p < 0.04). In four pairs and siamese newborns, malformations typical of monozygotic twins were present, such as an acardiac fetus with Trap sequence, a papyraceous fetus and two with hydroanencephaly. Twelve twins had malformations attributable to uterine compression. CONCLUSIONS: This study did not find a higher frequency of malformations comparing twins with single babies born alive, but in stillbirths there was a significant difference between single and twin stillbirths (7.1% versus 35.2%, respectively, p < 0.05).
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