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  • Title: [Gabapentin as adjuvant therapy in the treatment of refractory partial epilepsy].
    Author: Tomović M, Ilić T, Mihajlović M, Jovicić A.
    Journal: Vojnosanit Pregl; 1999; 56(2):151-6. PubMed ID: 10437420.
    Abstract:
    With the aim to evaluate the clinical efficacy and tolerability of gabapentin as an adjuvant therapy in patients with refractory partial epilepsy we conducted an open-randomized study, with 12-weeks follow-up period. The study included 18 epilepsy patients with unsatisfactorily controlled seizures, in spite of the treatment with 1 or 2 first line antiepileptic drug. Gabapentin was administered in a total daily dose between 900-1200 mg. Our results showed seizure frequency reduction by more than 50% in 72.2% patients, while the most frequent adverse effects were vertigo (16.67%) and ataxia (11.11%).
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