These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells.
    Author: Slominski A, Gomez-Sanchez CE, Foecking MF, Wortsman J.
    Journal: FEBS Lett; 1999 Jul 23; 455(3):364-6. PubMed ID: 10437805.
    Abstract:
    We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
    [Abstract] [Full Text] [Related] [New Search]