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  • Title: Oral desensitization to 5-aminosalicylic acid medications.
    Author: Stelzle RC, Squire EN.
    Journal: Ann Allergy Asthma Immunol; 1999 Jul; 83(1):23-4. PubMed ID: 10437811.
    Abstract:
    BACKGROUND: Although hypersensitive subjects have been desensitized to oral sulfasalazine, the feasibility of oral desensitization to the drug's active moiety, 5-aminosalicylic acid has been questioned and never been reported. METHODS: We devised a 5-aminosalicylic acid desensitization protocol and administered the drug to two hypersensitive subjects on three occasions. RESULTS: Both 5-aminosalicylic acid hypersensitive subjects were successfully desensitized without complications and were able to tolerate therapeutic doses. CONCLUSION: Despite changing the drug's properties by crushing it for incrementally increasing administration, we successfully desensitized two patients on three occasions with 5-aminosalicylic acid.
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