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  • Title: Effects of cyclosporin A on contractile activity and cytoskeleton in chick embryo cardiomyocytes.
    Author: Kołcz J, Drukała J, Jurkiewicz A, Pfitzner R, Garlicki M, Czyź J, Korohoda W.
    Journal: Biochem Cell Biol; 1999; 77(2):133-40. PubMed ID: 10438148.
    Abstract:
    The effects of cyclosporin A (CsA), a clinically used immunosupressive drug, on contractile activity of chick cardiomyocytes grown as small aggregates or explants suspended on a network of elastic glass fibres or cultured in a monolayer were analysed in vitro with computer-aided image cytometry methods. At therapeutic concentrations (200-1500 ng/mL), CsA induced changes in the frequency and amplitude of the beating activity of cardiomyocytes 15 min after application. Longer treatment of cardiomyocytes, for 20-24 h, additionally induced changes in their shape and cytoskeleton organization (F-actin and alpha-actinin distribution). These results indicate that CsA is able to affect directly the contractile activity, morphology, and cytoskeleton architecture of heart cells.
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