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  • Title: Functional residual capacity and pulmonary mechanics in premature infants receiving a 12-day dexamethasone course.
    Author: Lee M, Diah P, Krauss AN, Auld PA.
    Journal: Am J Perinatol; 1999; 16(3):151-6. PubMed ID: 10438197.
    Abstract:
    The objective of this paper is to determine the effects of a 12-day dexamethasone course of the pulmonary function of preterm infants. The design consisted of a consecutive sample of eligible patients, before-after trial. The Regional referral center neonatal ICU was the setting. The patients were 13 preterm infants, 545-1315 g, requiring mechanical ventilation. The following was used: Intravenous dexamethasone for a 12-day tapering course beginning at 0.5 mg/kg every 12 hr. Main outcome measures were as follows: Measurements of functional residual capacity (FRC), compliance, resistance, arterial blood gases and alveolar-arterial differences, level of ventilatory assistance, weight, length. All measures of pulmonary function demonstrated significant improvement by Day 12 of treatment. Most improvement occurred in the first 6 days of treatment, in association with increased lung volume.
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