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  • Title: Cytokines increase endothelin ETB receptor contractile activity in rat cerebral artery.
    Author: Leseth KH, Adner M, Berg HK, White LR, Aasly J, Edvinsson L.
    Journal: Neuroreport; 1999 Aug 02; 10(11):2355-9. PubMed ID: 10439463.
    Abstract:
    The plasticity of endothelin ETB receptor activity and the influence of pro-inflammatory cytokines was examined in cerebral artery. In fresh rat basilar artery, the selective ETB receptor agonist, sarafotoxin S6c, induced negligible contractions. However, after 1 day of organ culture, fully defined concentration-response curves were obtained in artery segments exposed to sarafotoxin S6c. Organ culture in the presence of either interleukin-1 beta or tumour necrosis factor-alpha, but not interleukin-2 or interleukin-6, further amplified the maximal contraction to sarafotoxin S6c. The plasticity of ETB receptor expression in cerebral arteries and sensitivity for pro-inflammatory cytokines, suggest a role in inflammatory cerebral diseases such as stroke.
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