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  • Title: [Treatment of transformed refractory migraine with intravenous dihydroergotamine].
    Author: Cid C, Ortega-Valín F, Valero M, Muñoz R, Pascual J.
    Journal: Neurologia; 1999; 14(6):315-8. PubMed ID: 10439626.
    Abstract:
    In this work we present our experience with a seven-day protocol of i.v. dihydroergotamine (DHE) in the treatment of 6 patients (7 treatments) suffering from intractable transformed migraine. All of them were admitted to hospital and treated for one week with a protocol which included DHE doses between 0.5-1 mg/8 h. One patient did not respond. The remaining 6 became free of pain in under 48 hours after the beginning of treatment. This positive effect remained for between 15 days and 3 months. All patients experienced adverse events; however, these were slight and ceased when the DHE dose was reduced. DHE is an effective and quick option for the short-term treatment of patients with severe transformed migraine resistant to other medications.
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