These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The effect of anticonvulsants on the nitric oxide content and level of lipid peroxidation in the brain of rats in model seizure states].
    Author: Bashkatova VG, Vitskova GIu, Narkevich VB, Mikoian VD, Vanin AF, Raevskiĭ KS.
    Journal: Eksp Klin Farmakol; 1999; 62(3):11-4. PubMed ID: 10439939.
    Abstract:
    EPR spectroscopy was performed to study the effect of anticonvulsants lamotrigine and phenobarbital on nitric oxide generation in rat brain on models of a convulsive seizure caused by exposure to maximal electric shock or corasole injection. The intensity of lipid peroxidation (LPO) was studied at the same time. The anticonvulsants under study proved to be capable of suppressing to a various degree intensification of nitric oxide generation and increase of LPO intensity in the rat cerebral cortex induced by convulsions. This widens the existing idea of the mechanism of the effect of antiepileptic agents.
    [Abstract] [Full Text] [Related] [New Search]