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  • Title: [Changes in the transmembrane potential of thymocytes during dexamethasone- and Ca2(+)-induced apoptosis].
    Author: Dukhanin AS, Patrashev DV, Ogurtsov SI.
    Journal: Eksp Klin Farmakol; 1999; 62(3):40-3. PubMed ID: 10439947.
    Abstract:
    By means of the method of potential-sensitive fluorescent probes is established that under dexametazone-induced apoptosis (0.1-10 microM) the reduction of transmembrane potentials (TMP, delta phi) on plasmatic (delta phi p) and mitochondrial (delta phi m) membranes of hormone-sensitive thymocytes is observed. Dexametazone does not changes transmembrane potentials of glucocorticoid-resistant thymocytes. Ca-ionophore A23187 realistically reduces (at the average on 26%) value of plasmatic TMP both in glucocorticoid-sensitive and glucocorticoid-resistant thymocytes. Change of delta phi is one of the mechanisms to realization an apoptotic process in rats' thymocytes. Dynamics and nature of TMP changes depend on the agent-inductor of apoptosis.
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