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  • Title: [The effect of thymogen on the postintoxication immunodeficiency state induced by acute acetonitrile poisoning].
    Author: Zabrodskiĭ PF.
    Journal: Eksp Klin Farmakol; 1999; 62(3):48-9. PubMed ID: 10439949.
    Abstract:
    It was demonstrated in experiments on Wistar rats that acute acetonitrile (AN) intoxication (0.8L D50) causes decrease of antibody-forming cells in the spleen, mainly those related to the T-dependent antigen, functioning of the natural cell-killers, antibody-dependent cytotoxicity, the ability of macrophages to induce the humoral immune responses and the delayed hypersensitivity reaction. Thymogen restored most of the humoral and cell immune reactions which were reduced by AN.
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