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  • Title: Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol.
    Author: Tanda G, Loddo P, Di Chiara G.
    Journal: Eur J Pharmacol; 1999 Jul 02; 376(1-2):23-6. PubMed ID: 10440085.
    Abstract:
    Rats were administered daily for 8 days with increasing doses (2-12 mg/kg/day) of delta9-tetrahydrocannabinol (delta9-THC) and than challenged with different doses of SR141716A, an antagonist of cannabinoid receptors. SR141716A dose dependently reduced dialysate dopamine (DA) in the nucleus accumbens shell and precipitated a physical withdrawal syndrome. No such effects were obtained after administration of SR141716A to saline controls.
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